論文 - 詳細
RRC ID | 35788 |
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著者 | Li C, Hisamoto N, Matsumoto K. |
タイトル | Axon Regeneration Is Regulated by Ets-C/EBP Transcription Complexes Generated by Activation of the cAMP/Ca2+ Signaling Pathways. |
ジャーナル | PLoS Genet |
Abstract |
The ability of specific neurons to regenerate their axons after injury is governed by cell-intrinsic regeneration pathways. In Caenorhabditis elegans, the JNK and p38 MAPK pathways are important for axon regeneration. Axonal injury induces expression of the svh-2 gene encoding a receptor tyrosine kinase, stimulation of which by the SVH-1 growth factor leads to activation of the JNK pathway. Here, we identify ETS-4 and CEBP-1, related to mammalian Ets and C/EBP, respectively, as transcriptional activators of svh-2 expression following axon injury. ETS-4 and CEBP-1 function downstream of the cAMP and Ca2+-p38 MAPK pathways, respectively. We show that PKA-dependent phosphorylation of ETS-4 promotes its complex formation with CEBP-1. Furthermore, activation of both cAMP and Ca2+ signaling is required for activation of svh-2 expression. Thus, the cAMP/Ca2+ signaling pathways cooperatively activate the JNK pathway, which then promotes axon regeneration. |
巻・号 | 11(10) |
ページ | e1005603 |
公開日 | 2015-10-1 |
DOI | 10.1371/journal.pgen.1005603 |
PII | PGENETICS-D-15-01003 |
PMID | 26484536 |
PMC | PMC4618690 |
MeSH | Animals Axons / metabolism* Axons / physiology CCAAT-Enhancer-Binding Proteins / biosynthesis CCAAT-Enhancer-Binding Proteins / genetics* Caenorhabditis elegans / genetics Caenorhabditis elegans / growth & development Caenorhabditis elegans Proteins / biosynthesis Caenorhabditis elegans Proteins / genetics* Calcium Signaling / genetics Cyclic AMP / genetics Cyclic AMP / metabolism Gene Expression Regulation, Developmental Intercellular Signaling Peptides and Proteins / biosynthesis Intercellular Signaling Peptides and Proteins / genetics MAP Kinase Signaling System / genetics Neurons / metabolism Phosphorylation Regeneration / genetics* Signal Transduction / genetics Transcription Factors / biosynthesis Transcription Factors / genetics* p38 Mitogen-Activated Protein Kinases / genetics |
IF | 5.175 |
引用数 | 29 |
WOS 分野 | GENETICS & HEREDITY |
リソース情報 | |
線虫 | tm2807 tm737 |