RRC ID 48863
著者 Ren P, Li W, Xue L.
タイトル GLYAT regulates JNK-mediated cell death in Drosophila.
ジャーナル Sci Rep
Abstract Cell death is a fundamental progress that regulates cell number, tissue homeostasis and organ size in development. The c-Jun N-terminal kinase (JNK) pathway has been evolutionarily conserved from fly to human, and plays essential roles in regulating cell death. To characterize additional genes that regulate JNK signaling, we performed a genetic screen in Drosophila and identified dGLYAT, a novel gene whose function was previously unknown, as a modulator of JNK-mediated cell death. We found that loss of dGLYAT suppressed JNK activation and cell death triggered by over-expression of Egr or Hep, or depletion of puc or lgl in development, suggesting dGLYAT regulates both ectopic and physiological functions of JNK pathway. Furthermore, we showed that loss of dGLYAT inhibits JNK-mediated ROS production, suggesting dGLYAT regulates multiple functions of JNK signaling in vivo.
巻・号 7(1)
ページ 5183
公開日 2017-7-12
DOI 10.1038/s41598-017-05482-y
PII 10.1038/s41598-017-05482-y
PMID 28701716
PMC PMC5507861
MeSH Acyltransferases / genetics Acyltransferases / metabolism* Animals Apoptosis / genetics Biomarkers Cell Death* / genetics Drosophila / embryology Drosophila / genetics Drosophila / metabolism* Ectopic Gene Expression Enzyme Activation Gene Expression Regulation, Developmental JNK Mitogen-Activated Protein Kinases / metabolism* Phenotype Reactive Oxygen Species Signal Transduction Transcriptional Regulator ERG / genetics Transcriptional Regulator ERG / metabolism
IF 3.998
引用数 3
WOS 分野 BIOCHEMISTRY & MOLECULAR BIOLOGY
リソース情報
ショウジョウバエ 5680R-2