RRC ID 2456
著者 Costagli A, Felice B, Guffanti A, Wilson SW, Mione M.
タイトル Identification of alternatively spliced dab1 isoforms in zebrafish.
ジャーナル Dev Genes Evol
Abstract We have investigated the genomic organization, the occurrence of alternative splicing and the differential expression of the zebrafish disabled1 (dab1) gene. Dab1 is a key effector of the Reelin pathway, which regulates neuronal migration during brain development in vertebrates. The coding region of the zebrafish dab1 gene spans over 600 kb of genomic DNA and is composed of 15 exons. Alternative splicing in a region enriched for tyrosine residues generates at least three different isoforms. These isoforms are developmentally regulated and show differential tissue expression. Comparison with mouse and human data shows an overall conservation of the genomic organization with different alternative splicing events generating species-specific isoforms. Because these alternative splicing events give rise to isoforms with different numbers of phosphorylateable tyrosines, we speculate that alternative splicing of the dab1 gene in zebrafish and in other vertebrates regulates the nature of the cellular response to the Reelin signal.
巻・号 216(6)
ページ 291-9
公開日 2006-6-1
DOI 10.1007/s00427-005-0052-5
PMID 16520940
PMC PMC2790411
MeSH Adaptor Proteins, Signal Transducing Alternative Splicing* Animals Animals, Genetically Modified Base Sequence Codon, Initiator Codon, Terminator DNA, Complementary Exons Gene Expression Regulation Humans In Situ Hybridization Introns Mice Molecular Sequence Data Nerve Tissue Proteins / genetics* Nerve Tissue Proteins / metabolism* Neurons / physiology Phylogeny Protein Isoforms / genetics Protein Isoforms / metabolism Reelin Protein Species Specificity Tyrosine / genetics Zebrafish / genetics*
IF 1.339
引用数 12
WOS 分野 EVOLUTIONARY BIOLOGY DEVELOPMENTAL BIOLOGY CELL BIOLOGY
リソース情報
ゼブラフィッシュ rw0