RRC ID 352
著者 Hirota Y, Sawamoto K, Takahashi K, Ueda R, Okano H.
タイトル The transmembrane protein, Tincar, is involved in the development of the compound eye in Drosophila melanogaster.
ジャーナル Dev Genes Evol
Abstract We previously cloned and characterized the Drosophila gene, tincar (tinc), which encodes a novel protein with eight putative transmembrane domains. Here, we have studied the expression pattern and functions of tinc during developmental processes. tinc mRNA is expressed in the central and peripheral nervous systems, and midgut during embryogenesis. In the third-instar larval eye disc, tinc mRNA is strongly expressed in all the differentiating ommatidial cells within and in the vicinity of the morphogenetic furrow. Loss-of-function analysis using the RNA-interference method revealed severe defects of eye morphogenesis during the late developmental stages. Our results suggested that tinc may have an indispensable role in the normal differentiation of ommatidial cells.
巻・号 215(2)
ページ 90-6
公開日 2005-2-1
DOI 10.1007/s00427-004-0452-y
PMID 15654626
MeSH Animals Cell Differentiation Drosophila Proteins / genetics Drosophila Proteins / physiology* Drosophila melanogaster / embryology* Drosophila melanogaster / genetics Drosophila melanogaster / growth & development Eye / cytology Eye / embryology* Eye / growth & development Membrane Proteins / genetics Membrane Proteins / physiology* RNA Interference RNA, Messenger / analysis RNA, Messenger / metabolism
IF 1.339
引用数 2
WOS 分野 EVOLUTIONARY BIOLOGY CELL BIOLOGY DEVELOPMENTAL BIOLOGY
リソース情報
ショウジョウバエ 7723R-1 7723R-3