| RRC ID |
11863
|
| 著者 |
Lee JE, Oh HA, Song H, Jun JH, Roh CR, Xie H, Dey SK, Lim HJ.
|
| タイトル |
Autophagy regulates embryonic survival during delayed implantation.
|
| ジャーナル |
Endocrinology
|
| Abstract |
Delayed implantation, considered a state of suspended animation, is widespread in mammals. Blastocysts under this condition remain dormant for an extended period but resume implantation competence upon favorable conditions. The underlying mechanism by which extended longevity of dormant blastocysts is maintained is not clearly understood. Using autophagy markers and the well-defined delayed implantation model in mice, we show that autophagy is important for the extended longevity of dormant blastocysts in utero during delayed implantation. However, prolonged dormancy leads to reduced developmental competency of blastocysts and cellular damage with compromised pregnancy outcome. Estrogen supplementation, which activates implantation of dormant blastocysts, induces the formation of multivesicular bodies in the trophectoderm in vivo. Collectively, our results suggest that autophagy is a critical cellular mechanism that is utilized for the prolonged survival of dormant blastocysts.
|
| 巻・号 |
152(5)
|
| ページ |
2067-75
|
| 公開日 |
2011-5-1
|
| DOI |
10.1210/en.2010-1456
|
| PII |
en.2010-1456
|
| PMID |
21363932
|
| MeSH |
Adenine / analogs & derivatives
Adenine / pharmacology
Animals
Autophagy / drug effects
Autophagy / physiology*
Blastocyst / metabolism*
Blastocyst / ultrastructure
Cell Survival / drug effects
Embryo Implantation / physiology*
Embryo, Mammalian / cytology
Embryo, Mammalian / embryology
Embryo, Mammalian / metabolism*
Estrogens / pharmacology
Female
Green Fluorescent Proteins / genetics
Green Fluorescent Proteins / metabolism
Male
Mice
Mice, Transgenic
Microscopy, Confocal
Microscopy, Electron, Transmission
Microtubule-Associated Proteins / genetics
Microtubule-Associated Proteins / metabolism
Multivesicular Bodies / metabolism
Multivesicular Bodies / ultrastructure
Pregnancy
Time Factors
|
| IF |
3.934
|
| 引用数 |
46
|
|
WOS 分野
|
ENDOCRINOLOGY & METABOLISM
|
| リソース情報 |
| 実験動物マウス |
RBRC00806 |
