RRC ID 18703
著者 Ohguchi K, Nakajima C, Oyama M, Iinuma M, Itoh T, Akao Y, Nozawa Y, Ito M.
タイトル Inhibitory effects of flavonoid glycosides isolated from the peel of Japanese persimmon (Diospyros kaki 'Fuyu') on melanin biosynthesis.
ジャーナル Biol Pharm Bull
Abstract We found that the acetone extract of the peel of Japanese persimmon (Diospyros kaki 'Fuyu') inhibits melanin biosynthesis in mouse B16 melanoma cells. The activity-guided purification of the extract resulted in isolation of two active compounds, which have been identified as flavonoid glycosides, isoquercitrin (quercetin-3-O-glucoside) and hyperin (quercetin-3-O-galactoside) by spectral analysis. Isoquercitrin and hyperin strongly inhibited the production of melanin (IC(50): 21.7 and 18.2 microM, respectively). The inhibitory effects were found to be mediated by suppression of tyrosinase expression.
巻・号 33(1)
ページ 122-4
公開日 2010-1-1
DOI 10.1248/bpb.33.122
PII JST.JSTAGE/bpb/33.122
PMID 20045948
MeSH Animals Cell Line, Tumor Diospyros / chemistry* Flavonoids / isolation & purification Flavonoids / pharmacology* Fruit Glucosides Melanins / biosynthesis* Mice Monophenol Monooxygenase / metabolism* Plant Extracts / chemistry Plant Extracts / pharmacology* Quercetin / analogs & derivatives
IF 1.863
引用数 23
WOS 分野 PHARMACOLOGY & PHARMACY
リソース情報
ヒト・動物細胞 B16 melanoma 4A5(RCB0557)