RRC ID 29324
著者 Nomura H, Isshiki Y, Sakuda K, Sakuma K, Kondo S.
タイトル Effects of oakmoss and its components on biofilm formation of Legionella pneumophila.
ジャーナル Biol Pharm Bull
Abstract Oakmoss and its components are known as antibacterial agents, specifically against Legionella pneumophila. In the present study, we investigated the effects of oakmoss and its components (phenol, didepside and isochromen derivatives) on L. pneumophila biofilm formation, with particular reference to the bactericidal activity (minimum bactericidal concentration; MBC) of these components against the bacterial cells in the biofilm. Of the 20 compounds tested, two didepside derivatives and four phenol derivatives reduced biofilm formation by more than 50% of that observed for the control at their respective minimum inhibitory concentrations (1/2×MIC). The inhibitory activities of these compounds were either equivalent to or greater than that of the clarithromycin reference. Isochromen derivatives had no effect on biofilm formation. Analysis of bactericidal activity of didepside and isochromen derivatives revealed that three of four didepside derivatives and one of four isochromen derivatives exhibited high bactericidal activity (MBC: 32.0-74.7 µg/mL) against the L. pneumophila in the biofilm after 24 h or 48 h of co-incubation; the antibacterial activities of these compounds were almost equivalent to clarithromycin and chlorhexidine gluconate (MBC: 42.7-64.0 µg/mL) that were used as references. Thus, based on their anti-biofilm forming and bactericidal activities, didepside derivatives are considered to be good candidates for disinfectants against L. pneumophila.
巻・号 36(5)
ページ 833-7
公開日 2013-1-1
DOI 10.1248/bpb.b12-01047
PII DN/JST.JSTAGE/bpb/b12-01047
PMID 23649339
MeSH Anti-Bacterial Agents / pharmacology* Biofilms / drug effects* Legionella pneumophila / drug effects* Legionella pneumophila / physiology Microbial Sensitivity Tests Resins, Plant / pharmacology* Terpenes / pharmacology*
IF 1.863
引用数 5
WOS 分野 PHARMACOLOGY & PHARMACY
リソース情報
一般微生物 JCM 7571