RRC ID 50043
著者 Dillard C, Narbonne-Reveau K, Foppolo S, Lanet E, Maurange C.
タイトル Two distinct mechanisms silence chinmo in Drosophila neuroblasts and neuroepithelial cells to limit their self-renewal.
ジャーナル Development
Abstract Whether common principles regulate the self-renewing potential of neural stem cells (NSCs) throughout the developing central nervous system is still unclear. In the Drosophila ventral nerve cord and central brain, asymmetrically dividing NSCs, called neuroblasts (NBs), progress through a series of sequentially expressed transcription factors that limits self-renewal by silencing a genetic module involving the transcription factor Chinmo. Here, we find that Chinmo also promotes neuroepithelium growth in the optic lobe during early larval stages by boosting symmetric self-renewing divisions while preventing differentiation. Neuroepithelium differentiation in late larvae requires the transcriptional silencing of chinmo by ecdysone, the main steroid hormone, therefore allowing coordination of neural stem cell self-renewal with organismal growth. In contrast, chinmo silencing in NBs is post-transcriptional and does not require ecdysone. Thus, during Drosophila development, humoral cues or tissue-intrinsic temporal specification programs respectively limit self-renewal in different types of neural progenitors through the transcriptional and post-transcriptional regulation of the same transcription factor.
巻・号 145(2)
公開日 2018-1-25
DOI 10.1242/dev.154534
PII dev.154534
PMID 29361557
MeSH Animals Cell Proliferation / physiology* Drosophila Proteins / genetics Drosophila Proteins / metabolism* Drosophila melanogaster Ecdysone / biosynthesis Ecdysone / genetics Gene Silencing / physiology* Nerve Tissue Proteins / genetics Nerve Tissue Proteins / metabolism* Neural Stem Cells / cytology Neural Stem Cells / metabolism* Neuroepithelial Cells / cytology Neuroepithelial Cells / metabolism*
IF 5.611
引用数 8
リソース情報
ショウジョウバエ 17156R-1