RRC ID 34811
著者 Hoffman CS, Wood V, Fantes PA.
タイトル An Ancient Yeast for Young Geneticists: A Primer on the Schizosaccharomyces pombe Model System.
ジャーナル Genetics
Abstract The fission yeast Schizosaccharomyces pombe is an important model organism for the study of eukaryotic molecular and cellular biology. Studies of S. pombe, together with studies of its distant cousin, Saccharomyces cerevisiae, have led to the discovery of genes involved in fundamental mechanisms of transcription, translation, DNA replication, cell cycle control, and signal transduction, to name but a few processes. However, since the divergence of the two species approximately 350 million years ago, S. pombe appears to have evolved less rapidly than S. cerevisiae so that it retains more characteristics of the common ancient yeast ancestor, causing it to share more features with metazoan cells. This Primer introduces S. pombe by describing the yeast itself, providing a brief description of the origins of fission yeast research, and illustrating some genetic and bioinformatics tools used to study protein function in fission yeast. In addition, a section on some key differences between S. pombe and S. cerevisiae is included for readers with some familiarity with budding yeast research but who may have an interest in developing research projects using S. pombe.
巻・号 201(2)
ページ 403-23
公開日 2015-10-1
DOI 10.1534/genetics.115.181503
PII 201/2/403
PMID 26447128
PMC PMC4596657
MeSH Chromosomes, Fungal / genetics* DNA Damage / genetics DNA Replication / genetics* Genome, Fungal Homologous Recombination / genetics* Life Cycle Stages / genetics Models, Genetic Research Schizosaccharomyces / genetics*
IF 4.015
引用数 75
WOS 分野 GENETICS & HEREDITY
リソース情報
酵母