| RRC ID |
33303
|
| 著者 |
Matsunaga E, Nambu S, Oka M, Tanaka M, Taoka M, Iriki A.
|
| タイトル |
Periostin, a neurite outgrowth-promoting factor, is expressed at high levels in the primate cerebral cortex.
|
| ジャーナル |
Dev Growth Differ
|
| Abstract |
Periostin (POSTN or osteoblast specific factor) is an extracellular matrix protein originally identified as a protein highly expressed in osteoblasts. Recently, periostin has been reported to function in axon regeneration and neuroprotection. In the present study, we focused on periostin function in cortical evolution. We performed a comparative gene expression analysis of periostin between rodents (mice) and primates (marmosets and macaques). Periostin was expressed at higher levels in the primate cerebral cortex compared to the mouse cerebral cortex. Furthermore, we performed overexpression experiments of periostin in vivo and in vitro. Periostin exhibited neurite outgrowth activity in cortical neurons. These results suggested the possibility that prolonged and increased periostin expression in the primate cerebral cortex enhances the cortical plasticity of the mammalian cerebral cortex.
|
| 巻・号 |
57(3)
|
| ページ |
200-8
|
| 公開日 |
2015-4-1
|
| DOI |
10.1111/dgd.12194
|
| PMID |
25703431
|
| MeSH |
Animals
Callithrix / metabolism*
Cell Adhesion Molecules / metabolism*
Cerebral Cortex / cytology
Cerebral Cortex / metabolism*
DNA Primers / genetics
Hippocampus / cytology
Immunohistochemistry
In Situ Hybridization
Macaca / metabolism*
Mice
Neurites / metabolism*
Neuronal Plasticity / physiology*
Plasmids / genetics
Rats
Species Specificity
|
| IF |
1.723
|
| 引用数 |
10
|
|
WOS 分野
|
DEVELOPMENTAL BIOLOGY
CELL BIOLOGY
|
| リソース情報 |
| ニホンザル |
|
