RRC ID 50848
著者 Kaneshima T, Myoda T, Toeda K, Fujimori T, Nishizawa M.
タイトル Antimicrobial constituents of peel and seeds of camu-camu (Myrciaria dubia).
ジャーナル Biosci Biotechnol Biochem
Abstract Various antimicrobial constituents of camu-camu fruit were isolated. Acylphloroglucinol (compound 1) and rhodomyrtone (compound 2) were isolated from the peel of camu-camu (Myrciaria dubia) fruit, while two other acylphloroglucinols (compounds 3 and 4) were obtained from camu-camu seeds. The structures of the isolated compounds were characterized by spectrophotometric methods. Compounds 1 and 4 were confirmed to be new acylphloroglucinols with different substituents at the C7 or C9 position of 2, and were named myrciarone A and B, respectively. Compound 3 was determined to be isomyrtucommulone B. This is the first report of the isolation of 3 from a natural resource. The antimicrobial activities of compounds 1, 3, and 4 were similar to those of 2, and the minimum inhibitory concentrations were either similar to or lower than that of kanamycin. These results suggest that the peel and seeds of camu-camu fruit could be utilized for therapeutic applications.
巻・号 81(8)
ページ 1461-1465
公開日 2017-8-1
DOI 10.1080/09168451.2017.1320517
PMID 28475419
MeSH Anti-Infective Agents / chemistry* Anti-Infective Agents / isolation & purification Anti-Infective Agents / pharmacology Candida albicans / drug effects Candida albicans / growth & development Fruit / chemistry* Gram-Negative Bacteria / drug effects Gram-Negative Bacteria / growth & development Gram-Positive Bacteria / drug effects Gram-Positive Bacteria / growth & development Kanamycin / pharmacology Microbial Sensitivity Tests Molecular Structure Myrtaceae / chemistry* Phloroglucinol / analogs & derivatives Phloroglucinol / isolation & purification* Phloroglucinol / pharmacology Plant Extracts / chemistry Saccharomyces cerevisiae / drug effects Saccharomyces cerevisiae / growth & development Seeds / chemistry* Xanthones / chemistry* Xanthones / isolation & purification Xanthones / pharmacology
IF 1.516
引用数 7
リソース情報
一般微生物 JCM 1465 JCM 5175 JCM 18426 JCM 5962 JCM 2085