RRC ID 45532
著者 Brandt JP, Ringstad N.
タイトル Toll-like Receptor Signaling Promotes Development and Function of Sensory Neurons Required for a C. elegans Pathogen-Avoidance Behavior.
ジャーナル Curr Biol
Abstract Toll-like receptors (TLRs) play critical roles in innate immunity in many animal species. The sole TLR of C. elegans--TOL-1--is required for a pathogen-avoidance behavior, yet how it promotes this behavior is unknown. We show that for pathogen avoidance TOL-1 signaling is required in the chemosensory BAG neurons, where it regulates gene expression and is necessary for their chemosensory function. Genetic studies revealed that TOL-1 acts together with many conserved components of TLR signaling. BAG neurons are activated by carbon dioxide (CO₂), and we found that this modality is required for pathogen avoidance. TLR signaling can therefore mediate host responses to microbes through an unexpected mechanism: by promoting the development and function of chemosensory neurons that surveil the metabolic activity of environmental microbes.
巻・号 25(17)
ページ 2228-37
公開日 2015-8-31
DOI 10.1016/j.cub.2015.07.037
PII S0960-9822(15)00871-4
PMID 26279230
PMC PMC4642686
MeSH Animals Avoidance Learning Caenorhabditis elegans / genetics* Caenorhabditis elegans / metabolism Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / metabolism Carbon Dioxide / metabolism Cues Gene Expression* Nerve Tissue Proteins / genetics Nerve Tissue Proteins / metabolism Sensory Receptor Cells / metabolism Serratia marcescens / physiology* Signal Transduction*
IF 9.601
引用数 43
WOS 分野 BIOCHEMISTRY & MOLECULAR BIOLOGY CELL BIOLOGY
リソース情報
線虫 tm2816