論文 - 詳細
| RRC ID | 51165 |
|---|---|
| 著者 | Kim BJ, Kim BR, Kook YH, Kim BJ. |
| タイトル | A temperature sensitive Mycobacterium paragordonae induces enhanced protective immune responses against mycobacterial infections in the mouse model. |
| ジャーナル | Sci Rep |
| Abstract |
Recently, we introduced a temperature sensitive Mycobacterium spp., Mycobacterium paragordonae (Mpg). Here, we checked its potential as a candidate for live vaccination against Mycobacterium tuberculosis and Mycobacterium abscessus. Intravenous infections of mice with Mpg led to lower colony forming units (CFUs) compared to infection with BCG, suggesting its usefulness as a live vaccine. The analyses of immune responses indicated that the highly protective immunity elicited by Mpg was dependent on effective dendritic maturation, shift of cytokine patterns and antibody production toward a Th1 phenotype, and enhanced cytotoxic T cell response. Compared to BCG, Mpg showed a more effective protective immune response in the vaccinated mice against challenges with 2 different mycobacterial strains, M. tuberculosis H37Ra or M. abscessus Asan 50594. Our data suggest that a temperature sensitive Mpg may be a potentially powerful candidate vaccine strain to induce enhanced protective immune responses against M. tuberculosis and M. abscessus. |
| 巻・号 | 7(1) |
| ページ | 15230 |
| 公開日 | 2017-11-9 |
| DOI | 10.1038/s41598-017-15458-7 |
| PII | 10.1038/s41598-017-15458-7 |
| PMID | 29123166 |
| PMC | PMC5680210 |
| MeSH | Animals Antibodies, Bacterial / blood Cytokines / metabolism Dendritic Cells / immunology Hot Temperature Mice, Inbred BALB C Mutation* Mycobacterium Infections, Nontuberculous / prevention & control* Nontuberculous Mycobacteria / genetics Nontuberculous Mycobacteria / growth & development Nontuberculous Mycobacteria / immunology* Nontuberculous Mycobacteria / radiation effects T-Lymphocytes, Cytotoxic / immunology Th1 Cells / immunology Tuberculosis / prevention & control* Tuberculosis Vaccines / administration & dosage Tuberculosis Vaccines / immunology* Tuberculosis Vaccines / isolation & purification Vaccines, Attenuated / administration & dosage Vaccines, Attenuated / immunology Vaccines, Attenuated / isolation & purification |
| IF | 3.998 |
| 引用数 | 5 |
| リソース情報 | |
| 一般微生物 | JCM 18565 JCM 17638 |