RRC ID 48000
著者 Leitão-Gonçalves R, Carvalho-Santos Z, Francisco AP, Fioreze GT, Anjos M, Baltazar C, Elias AP, Itskov PM, Piper MDW, Ribeiro C.
タイトル Commensal bacteria and essential amino acids control food choice behavior and reproduction.
ジャーナル PLoS Biol
Abstract Choosing the right nutrients to consume is essential to health and wellbeing across species. However, the factors that influence these decisions are poorly understood. This is particularly true for dietary proteins, which are important determinants of lifespan and reproduction. We show that in Drosophila melanogaster, essential amino acids (eAAs) and the concerted action of the commensal bacteria Acetobacter pomorum and Lactobacilli are critical modulators of food choice. Using a chemically defined diet, we show that the absence of any single eAA from the diet is sufficient to elicit specific appetites for amino acid (AA)-rich food. Furthermore, commensal bacteria buffer the animal from the lack of dietary eAAs: both increased yeast appetite and decreased reproduction induced by eAA deprivation are rescued by the presence of commensals. Surprisingly, these effects do not seem to be due to changes in AA titers, suggesting that gut bacteria act through a different mechanism to change behavior and reproduction. Thus, eAAs and commensal bacteria are potent modulators of feeding decisions and reproductive output. This demonstrates how the interaction of specific nutrients with the microbiome can shape behavioral decisions and life history traits.
巻・号 15(4)
ページ e2000862
公開日 2017-4-1
DOI 10.1371/journal.pbio.2000862
PII pbio.2000862
PMID 28441450
PMC PMC5404834
MeSH Acetobacter / genetics Acetobacter / growth & development Acetobacter / physiology* Acetobacteraceae / genetics Acetobacteraceae / growth & development Acetobacteraceae / physiology Amino Acids, Essential / administration & dosage Amino Acids, Essential / analysis Amino Acids, Essential / deficiency Amino Acids, Essential / metabolism* Animals Animals, Genetically Modified Appetite Regulation Behavior, Animal Complex Mixtures / administration & dosage Complex Mixtures / chemistry Drosophila Proteins / antagonists & inhibitors Drosophila Proteins / genetics Drosophila Proteins / metabolism Drosophila melanogaster / genetics Drosophila melanogaster / microbiology* Drosophila melanogaster / physiology Enterococcus faecalis / genetics Enterococcus faecalis / growth & development Enterococcus faecalis / physiology Feeding Behavior* Female Food Preferences Gastrointestinal Microbiome* Gene Knockout Techniques Host-Parasite Interactions Lactobacillus / genetics Lactobacillus / growth & development Lactobacillus / physiology* Oviposition Species Specificity Symbiosis* Yeast, Dried / chemistry
IF 7.076
引用数 87
WOS 分野 BIOLOGY BIOCHEMISTRY & MOLECULAR BIOLOGY
リソース情報
ショウジョウバエ 7399R-3