RRC ID 45237
著者 Watanabe K, Hosono T, Watanabe K, Hosono-Fukao T, Ariga T, Seki T.
タイトル Diallyl trisulfide induces apoptosis in Jurkat cells by the modification of cysteine residues in thioredoxin.
ジャーナル Biosci Biotechnol Biochem
Abstract We reported the regulation of protein function by oxidative modification of the specific cysteine residue(s) by diallyl trisulfide (DATS). In this study, we examined if DATS modifies the cysteine residue of thioredoxin (Trx) by urea-polyacryl amide gel electrophoresis. DATS modified two specific cysteine residues in Trx and this oxidative modification of cysteine residues would be sole causative of the apoptosis induced by DATS in leukemic cells.
巻・号 78(8)
ページ 1418-20
公開日 2014-1-1
DOI 10.1080/09168451.2014.921564
PMID 25130747
MeSH Allyl Compounds / pharmacology* Antineoplastic Agents / pharmacology* Apoptosis / drug effects* Caspases / metabolism Cysteine / metabolism* Enzyme Activation / drug effects Humans Jurkat Cells Poly(ADP-ribose) Polymerases / metabolism Proteolysis / drug effects Sulfides / pharmacology* Thioredoxins / chemistry* Thioredoxins / metabolism*
IF 1.516
引用数 4
WOS 分野 FOOD SCIENCE & TECHNOLOGY BIOTECHNOLOGY & APPLIED MICROBIOLOGY CHEMISTRY, APPLIED BIOCHEMISTRY & MOLECULAR BIOLOGY
リソース情報
ヒト・動物細胞 Jurkat