RRC ID 50335
著者 Borensztejn A, Mascaro A, Wharton KA.
タイトル JAK/STAT signaling prevents excessive apoptosis to ensure maintenance of the interfollicular stalk critical for Drosophila oogenesis.
ジャーナル Dev Biol
Abstract Apoptosis not only eliminates cells that are damaged or dangerous but also cells whose function during development in patterning or organogenesis is complete. The successful formation of germ cells is essential for the perpetuation of a species. The production of an oocyte often depends on signaling between germline and somatic cells, but also between specialized types of somatic cells. In Drosophila, each developing egg chamber is separated from the next by a single file of interfollicular somatic cells. Little is known about the function of the interfollicular stalk, although its presumed role in separating egg chambers is to ensure that patterning cues from one egg chamber do not impact or disrupt the development of adjacent egg chambers. We found that cells comprising the stalk undergo a progressive decrease in number during oogenesis through an apoptotic-dependent loss. The extent of programmed cell death is restricted by JAK/STAT signaling in a cell-autonomous manner to ensure that the stalk is maintained. Both a failure to undergo the normal reduction in stalk cell number, or to prevent excessive stalk cell apoptosis results in a decrease in fecundity. Thus, activation of JAK/STAT signaling in the Drosophila interfollicular stalk emerges as a model to study the tight regulation of signaling-dependent apoptosis.
巻・号 438(1)
ページ 1-9
公開日 2018-6-1
DOI 10.1016/j.ydbio.2018.03.018
PII S0012-1606(17)30686-3
PMID 29571611
PMC PMC5951713
MeSH Animals Apoptosis / genetics* Cell Count Drosophila / metabolism Drosophila Proteins / metabolism Female Immunohistochemistry Janus Kinases / metabolism* Oogenesis / genetics* Oogenesis / physiology Ovarian Follicle / cytology Ovarian Follicle / physiology Ovary / cytology* Ovary / metabolism Ovary / physiology STAT Transcription Factors / metabolism* Signal Transduction / physiology
IF 2.896
引用数 4
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