RRC ID 46763
著者 Hudry B, Khadayate S, Miguel-Aliaga I.
タイトル The sexual identity of adult intestinal stem cells controls organ size and plasticity.
ジャーナル Nature
Abstract Sex differences in physiology and disease susceptibility are commonly attributed to developmental and/or hormonal factors, but there is increasing realization that cell-intrinsic mechanisms play important and persistent roles. Here we use the Drosophila melanogaster intestine to investigate the nature and importance of cellular sex in an adult somatic organ in vivo. We find that the adult intestinal epithelium is a cellular mosaic of different sex differentiation pathways, and displays extensive sex differences in expression of genes with roles in growth and metabolism. Cell-specific reversals of the sexual identity of adult intestinal stem cells uncovers the key role this identity has in controlling organ size, reproductive plasticity and response to genetically induced tumours. Unlike previous examples of sexually dimorphic somatic stem cell activity, the sex differences in intestinal stem cell behaviour arise from intrinsic mechanisms that control cell cycle duration and involve a new doublesex- and fruitless-independent branch of the sex differentiation pathway downstream of transformer. Together, our findings indicate that the plasticity of an adult somatic organ is reversibly controlled by its sexual identity, imparted by a new mechanism that may be active in more tissues than previously recognized.
巻・号 530(7590)
ページ 344-8
公開日 2016-2-18
DOI 10.1038/nature16953
PII nature16953
PMID 26887495
PMC PMC4800002
MeSH Adult Stem Cells / cytology* Animals Cell Cycle Cell Proliferation Cell Transformation, Neoplastic Dosage Compensation, Genetic Drosophila Proteins / metabolism Drosophila melanogaster / anatomy & histology* Drosophila melanogaster / cytology* Drosophila melanogaster / genetics Drosophila melanogaster / growth & development Female Intestines / cytology* Male Nuclear Proteins / metabolism Organ Size* RNA-Binding Proteins / metabolism Reproduction Ribonucleoproteins / metabolism Sex Characteristics* Sex Differentiation / genetics
IF 42.779
引用数 61
WOS 分野 GENETICS & HEREDITY
リソース情報
ショウジョウバエ 16724-R2