RRC ID 10998
著者 Ding Y, Liang C, Yang SY, Ra JC, Choi EM, Kim JA, Kim YH.
タイトル Phenolic compounds from Artemisia iwayomogi and their effects on osteoblastic MC3T3-E1 cells.
ジャーナル Biol Pharm Bull
Abstract One new (4) and twelve known phenolic compounds (1-3, 5-13) were isolated from a 70% MeOH extract of the aerial parts of Artemisia iwayomogi. The new compound was identified as 7,8-dimethoxy-coumarin-9-O-(6'-O-(E)-coumaroyl)-beta-D-glucopyranoside (4) and named iwayomin. The effects of compounds 1-13 on the function of osteoblastic MC3T3-E1 cells were examined by evaluating cell viability, alkaline phosphatase (ALP) activity, collagen synthesis, and mineralization in the presence of each compound. Compounds 3, 4, 7, and 9 showed potential in stimulating osteoblastic bone formation and may be useful for the prevention and/or treatment of osteoporosis.
巻・号 33(8)
ページ 1448-53
公開日 2010-1-1
DOI 10.1248/bpb.33.1448
PII JST.JSTAGE/bpb/33.1448
PMID 20686247
MeSH Alkaline Phosphatase / metabolism Animals Artemisia / chemistry* Calcium / metabolism Cell Line Cell Survival / drug effects Collagen / metabolism Magnetic Resonance Spectroscopy Mice Mice, Inbred C57BL Molecular Structure Osteoblasts / drug effects* Osteoblasts / enzymology Osteoporosis / prevention & control Phenols / isolation & purification Phenols / pharmacology* Plant Components, Aerial / chemistry Plant Extracts / isolation & purification Plant Extracts / pharmacology* Spectrometry, Mass, Electrospray Ionization
IF 1.863
引用数 13
WOS 分野 PHARMACOLOGY & PHARMACY
リソース情報
ヒト・動物細胞 MC3T3-E1(RCB1126)