RRC ID 32484
著者 Tsurui-Nishimura N, Nguyen TQ, Katsuyama T, Minami T, Furuhashi H, Oshima Y, Kurata S.
タイトル Ectopic antenna induction by overexpression of CG17836/Xrp1 encoding an AT-hook DNA binding motif protein in Drosophila.
ジャーナル Biosci Biotechnol Biochem
Abstract Drosophila imaginal discs are an excellent model system for studies of developmental plasticity. In imaginal discs, most cells adhere strictly to their specific identity, but some cells undergo transdetermination, a process wherein the determined identity switches to another disc-specific identity. In this study, we performed gain-of-function screening and identified a gene, CG17836/Xrp1, that induces ectopic antennae in the eye field upon overexpression at the early eye disc stage. An essential factor in the distalization process, Distalles, and its upstream regulators Wingless, Hedgehog, and Decapentaplegic, are ectopically induced by CG17836/Xrp1 overexpression in eye discs, and this provides molecular evidence of the formation of ectopic antennae. Further, forced expression of CG17836/Xrp1 induced severe cell-proliferation defects. These findings suggest that CG17836/Xrp1 is involved in the regulation of cell proliferation in eye discs and affects disc identity specification.
巻・号 77(2)
ページ 339-44
公開日 2013-2-7
DOI 10.1271/bbb.120756
PII DN/JST.JSTAGE/bbb/120756
PMID 23391928
MeSH Animals Arthropod Antennae / growth & development Arthropod Antennae / metabolism* Cell Proliferation Cell Transdifferentiation Compound Eye, Arthropod / growth & development Compound Eye, Arthropod / metabolism* DNA-Binding Proteins / genetics* DNA-Binding Proteins / metabolism Drosophila Proteins / genetics* Drosophila Proteins / metabolism Drosophila melanogaster / genetics* Drosophila melanogaster / growth & development Drosophila melanogaster / metabolism Gene Expression Regulation, Developmental* Hedgehog Proteins / genetics Hedgehog Proteins / metabolism Homeodomain Proteins / genetics Homeodomain Proteins / metabolism Imaginal Discs / growth & development Imaginal Discs / metabolism* Morphogenesis / genetics Transcription Factors / genetics Transcription Factors / metabolism Wnt1 Protein / genetics Wnt1 Protein / metabolism
IF 1.516
引用数 7
WOS 分野 FOOD SCIENCE & TECHNOLOGY BIOTECHNOLOGY & APPLIED MICROBIOLOGY CHEMISTRY, APPLIED BIOCHEMISTRY & MOLECULAR BIOLOGY
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