RRC ID 47784
著者 Hevia CF, López-Varea A, Esteban N, de Celis JF.
タイトル A Search for Genes Mediating the Growth-Promoting Function of TGFβ in the Drosophila melanogaster Wing Disc.
ジャーナル Genetics
Abstract Transforming Growth Factor β (TGFβ) signaling has a complex influence on cell proliferation, acting to stop cell division in differentiating cells, but also promoting cell division in immature cells. The activity of the pathway in Drosophila is mostly required to stimulate the proliferation of neural and epithelial tissues. Most interestingly, this function is not absolutely required for cell division, but it is needed for these tissues to reach their correct size. It is not known how TGFβ signaling promotes cell division in imaginal discs, or what the interactions between TGFβ activity and other signaling pathways regulating cell proliferation are. In this work, we have explored the disc autonomous function of TGFβ that promotes wing imaginal disc growth. We have studied the genetic interactions between TGFβ signaling and other pathways regulating wing disc growth, such as the Insulin and Hippo/Salvador/Warts pathways, as well as cell cycle regulators. We have also identified a collection of TGFβ candidate target genes affecting imaginal growth using expression profiles. These candidates correspond to genes participating in the regulation of a variety of biochemical processes, including different aspects of cell metabolism, suggesting that TGFβ could affect cell proliferation by regulating the metabolic fitness of imaginal cells.
巻・号 206(1)
ページ 231-249
公開日 2017-5-1
DOI 10.1534/genetics.116.197228
PII genetics.116.197228
PMID 28315837
PMC PMC5419472
MeSH Animals Cell Cycle Proteins / genetics* Cell Division / genetics Cell Proliferation / genetics Cell Size Drosophila Proteins / genetics* Drosophila melanogaster / genetics* Drosophila melanogaster / growth & development Gene Expression Regulation, Developmental Genetic Fitness Imaginal Discs / growth & development Insulin / genetics Intracellular Signaling Peptides and Proteins / genetics* Protein Kinases / genetics* Protein Serine-Threonine Kinases / genetics* Signal Transduction Transcriptome Transforming Growth Factor beta / biosynthesis Transforming Growth Factor beta / genetics* Wings, Animal / growth & development
IF 4.015
引用数 3
WOS 分野 GENETICS & HEREDITY
リソース情報
ショウジョウバエ 1395R-2 2262R-1