RRC ID |
35949
|
著者 |
Han H, Fan J, Xiong Y, Wu W, Lu Y, Zhang L, Zhao Y.
|
タイトル |
Chi and dLMO function antagonistically on Notch signaling through directly regulation of fng transcription.
|
ジャーナル |
Sci Rep
|
Abstract |
Gene apterous (ap), chip (chi) and beadex (bx) play important roles in the dorsal-ventral compartmentalization in Drosophila wing discs. Meanwhile, Notch signaling is essential to the same process. It has been reported that Ap and Chi function as a tetramer to regulate Notch signaling. At the same time, dLMO (the protein product of gene bx) regulates the activity of Ap by competing its binding with Chi. However, the detailed functions of Chi and dLMO on Notch signaling and the relevant mechanisms remain largely unknown. Here, we report the detailed functions of Chi and dLMO on Notch signaling. Different Chi protein levels in adjacent cells could activate Notch signaling mainly in the cells with higher level of Chi. dLMO could induce antagonistical phenotypes on Notch signaling compared to that induced by Chi. These processes depend on their direct regulation of fringe (fng) transcription.
|
巻・号 |
6
|
ページ |
18937
|
公開日 |
2016-1-7
|
DOI |
10.1038/srep18937
|
PII |
srep18937
|
PMID |
26738424
|
PMC |
PMC4704065
|
MeSH |
Animals
Cell Line
Drosophila Proteins / genetics*
Drosophila Proteins / metabolism*
Drosophila Proteins / physiology*
Drosophila melanogaster / metabolism*
Homeodomain Proteins / physiology*
N-Acetylglucosaminyltransferases / genetics*
N-Acetylglucosaminyltransferases / metabolism
Nuclear Proteins / physiology*
Protein Multimerization
Receptors, Notch / metabolism*
Signal Transduction
Transcription, Genetic
Transcriptional Activation
|
IF |
3.998
|
引用数 |
2
|
WOS 分野
|
CELL BIOLOGY
|
リソース情報 |
ショウジョウバエ |
|