RRC ID 35714
著者 Chen C, Buhl E, Xu M, Croset V, Rees JS, Lilley KS, Benton R, Hodge JJ, Stanewsky R.
タイトル Drosophila Ionotropic Receptor 25a mediates circadian clock resetting by temperature.
ジャーナル Nature
Abstract Circadian clocks are endogenous timers adjusting behaviour and physiology with the solar day. Synchronized circadian clocks improve fitness and are crucial for our physical and mental well-being. Visual and non-visual photoreceptors are responsible for synchronizing circadian clocks to light, but clock-resetting is also achieved by alternating day and night temperatures with only 2-4 °C difference. This temperature sensitivity is remarkable considering that the circadian clock period (~24 h) is largely independent of surrounding ambient temperatures. Here we show that Drosophila Ionotropic Receptor 25a (IR25a) is required for behavioural synchronization to low-amplitude temperature cycles. This channel is expressed in sensory neurons of internal stretch receptors previously implicated in temperature synchronization of the circadian clock. IR25a is required for temperature-synchronized clock protein oscillations in subsets of central clock neurons. Extracellular leg nerve recordings reveal temperature- and IR25a-dependent sensory responses, and IR25a misexpression confers temperature-dependent firing of heterologous neurons. We propose that IR25a is part of an input pathway to the circadian clock that detects small temperature differences. This pathway operates in the absence of known 'hot' and 'cold' sensors in the Drosophila antenna, revealing the existence of novel periphery-to-brain temperature signalling channels.
巻・号 527(7579)
ページ 516-20
公開日 2015-11-26
DOI 10.1038/nature16148
PII nature16148
PMID 26580016
MeSH Animals CLOCK Proteins / metabolism Circadian Clocks / physiology* Circadian Rhythm / physiology* Drosophila Proteins / genetics Drosophila Proteins / metabolism* Drosophila melanogaster / cytology Drosophila melanogaster / physiology* Extremities / innervation Female Male Mechanoreceptors / cytology Mechanoreceptors / metabolism Receptors, Ionotropic Glutamate / genetics Receptors, Ionotropic Glutamate / metabolism* Sensory Receptor Cells / metabolism Temperature*
IF 42.779
引用数 74
WOS 分野 NEUROSCIENCES
リソース情報
ショウジョウバエ 15627R-1 15627R-2