RRC ID 33105
著者 Belobrajdic DP, Jobling SA, Morell MK, Taketa S, Bird AR.
タイトル Wholegrain barley β-glucan fermentation does not improve glucose tolerance in rats fed a high-fat diet.
ジャーナル Nutr Res
Abstract Fermentation of oat and barley β-glucans is believed to mediate in part their metabolic health benefits, but the exact mechanisms remain unclear. In this study, we sought to test the hypothesis that barley β-glucan fermentation raises circulating incretin hormone levels and improves glucose control, independent of other grain components. Male Sprague-Dawley rats (n = 30) were fed a high-fat diet for 6 weeks and then randomly allocated to 1 of 3 dietary treatments for 2 weeks. The low- (LBG, 0% β-glucan) and high- (HBG, 3% β-glucan) β-glucan diets contained 25% wholegrain barley and similar levels of insoluble dietary fiber, available carbohydrate, and energy. A low-fiber diet (basal) was included for comparison. Immediately prior to the dietary intervention, gastric emptying rate (using the (13)C-octanoic breath test) and postprandial glycemic response of each diet were determined. At the end of the study, circulating gut hormone levels were determined; and a glucose tolerance test was performed. The rats were then killed, and indices of cecal fermentation were assessed. Diet did not affect live weight; however, the HBG diet, compared to basal and LBG, reduced food intake, tended to slow gastric emptying, increased cecal digesta mass and individual and total short-chain fatty acid pools, and lowered digesta pH. In contrast, circulating levels of glucose, insulin, gastric-inhibitory peptide, and glucagon-like peptide-1, and glucose tolerance were unaffected by diet. In conclusion, wholegrain barley β-glucan suppressed feed intake and increased cecal fermentation but did not improve postprandial glucose control or insulin sensitivity.
巻・号 35(2)
ページ 162-8
公開日 2015-2-1
DOI 10.1016/j.nutres.2014.12.006
PII S0271-5317(14)00285-1
PMID 25622537
MeSH Animals Blood Glucose Cecum / microbiology* Diet, High-Fat / adverse effects* Dietary Fiber / administration & dosage Eating / drug effects* Fermentation / drug effects* Gastric Inhibitory Polypeptide / metabolism Glucagon-Like Peptide 1 / metabolism Glucose Tolerance Test Hordeum / chemistry* Insulin / blood Male Rats Rats, Sprague-Dawley beta-Glucans / administration & dosage beta-Glucans / pharmacology*
IF 2.767
引用数 15
WOS 分野 NUTRITION & DIETETICS
リソース情報
オオムギ barley low beta glucan mutant