RRC ID 47313
著者 Seo M, Park S, Nam HG, Lee SJ.
タイトル RNA helicase SACY-1 is required for longevity caused by various genetic perturbations in Caenorhabditis elegans.
ジャーナル Cell Cycle
Abstract RNA helicases, which unwind RNAs, are essential for RNA metabolism and homeostasis. However, the roles of RNA helicases in specific physiological processes remain poorly understood. We recently reported that an RNA helicase, HEL-1, promotes long lifespan conferred by reduced insulin/insulin-like growth factor-1 (IGF-1) signaling (IIS) in Caenorhabditis elegans. We also showed that HEL-1 induces the expression of longevity genes by physically interacting with Forkhead box O (FOXO) transcription factor. Thus, the HEL-1 RNA helicase appears to regulate lifespan by specifically activating FOXO in IIS. In the current study, we report another longevity-promoting RNA helicase, Suppressor of ACY-4 sterility 1 (SACY-1). SACY-1 contributed to the longevity of daf-2/insulin/IGF-1 receptor mutants. Unlike HEL-1, SACY-1 was also required for the longevity due to mutations in genes involved in non-IIS pathways. Thus, SACY-1 appears to function as a general longevity factor for various signaling pathways, which is different from the specific function of HEL-1.
巻・号 15(14)
ページ 1821-9
公開日 2016-7-17
DOI 10.1080/15384101.2016.1183845
PMID 27153157
PMC PMC4968901
MeSH Amino Acid Sequence Animals Caenorhabditis elegans / genetics* Caenorhabditis elegans / physiology* Caenorhabditis elegans Proteins / chemistry Caenorhabditis elegans Proteins / metabolism* DEAD-box RNA Helicases / chemistry DEAD-box RNA Helicases / metabolism* Insulin / metabolism Longevity / genetics* Mutation / genetics Receptor, IGF Type 1 / metabolism Reproduction Signal Transduction Stress, Physiological
IF 3.699
引用数 2
WOS 分野 CELL BIOLOGY
リソース情報
線虫 DG3485 sacy-1(tm5503) I tnEx159[sacy-1p::gfp::sacy-1 unc-119(+)]