RRC ID 36438
著者 Yoshimi K, Kumada S, Weitemier A, Jo T, Inoue M.
タイトル Reward-Induced Phasic Dopamine Release in the Monkey Ventral Striatum and Putamen.
ジャーナル PLoS One
Abstract In-vivo voltammetry has successfully been used to detect dopamine release in rodent brains, but its application to monkeys has been limited. We have previously detected dopamine release in the caudate of behaving Japanese monkeys using diamond microelectrodes (Yoshimi 2011); however it is not known whether the release pattern is the same in various areas of the forebrain. Recent studies have suggested variations in the dopaminergic projections to forebrain areas. In the present study, we attempted simultaneous recording at two locations in the striatum, using fast-scan cyclic voltammetry (FSCV) on carbon fibers, which has been widely used in rodents. Responses to unpredicted food and liquid rewards were detected repeatedly. The response to the liquid reward after conditioned stimuli was enhanced after switching the prediction cue. These characteristics were generally similar between the ventral striatum and the putamen. Overall, the technical application of FSCV recording in multiple locations was successful in behaving primates, and further voltammetric recordings in multiple locations will expand our knowledge of dopamine reward responses.
巻・号 10(6)
ページ e0130443
公開日 2015-1-1
DOI 10.1371/journal.pone.0130443
PII PONE-D-14-47094
PMID 26110516
PMC PMC4482386
MeSH Animals Behavior, Animal / physiology* Brain / physiology Dopamine / metabolism* Electric Stimulation Food Macaca / physiology Microelectrodes Putamen / metabolism* Putamen / physiology Reward Ventral Striatum / metabolism* Ventral Striatum / physiology
IF 2.74
引用数 10
WOS 分野 NEUROSCIENCES
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