RRC ID 36450
著者 Murata Y, Higo N, Oishi T, Isa T.
タイトル Increased expression of the growth-associated protein-43 gene after primary motor cortex lesion in macaque monkeys.
ジャーナル Neurosci Res
Abstract We recently showed that changes of brain activity in the ipsilesional ventral premotor cortex (PMv) and perilesional primary motor cortex (M1) of macaque monkeys were responsible for recovery of manual dexterity after lesioning M1. To investigate whether axonal remodeling is associated with M1 lesion-induced changes in brain activity, we assessed gene expression of growth-associated protein-43 (GAP-43) in motor and premotor cortices. Increased expression was observed in the PMv during the period just after recovery and in the perilesional M1 during the plateau phase of recovery. Time-dependent and brain region-specific remodeling may play a role in functional recovery after lesioning M1.
巻・号 98
ページ 64-9
公開日 2015-9-1
DOI 10.1016/j.neures.2015.04.007
PII S0168-0102(15)00134-0
PMID 25959053
MeSH Animals Female GAP-43 Protein / metabolism* Hand / physiopathology Ibotenic Acid / toxicity Macaca Male Motor Cortex / drug effects Motor Cortex / metabolism* Motor Cortex / pathology Movement Time Factors
IF 2.645
引用数 2
WOS 分野 NEUROSCIENCES
リソース情報
ニホンザル