RRC ID 49654
著者 Blyth J, Makrantoni V, Barton RE, Spanos C, Rappsilber J, Marston AL.
タイトル Genes Important for Schizosaccharomyces pombe Meiosis Identified Through a Functional Genomics Screen.
ジャーナル Genetics
Abstract Meiosis is a specialized cell division that generates gametes, such as eggs and sperm. Errors in meiosis result in miscarriages and are the leading cause of birth defects; however, the molecular origins of these defects remain unknown. Studies in model organisms are beginning to identify the genes and pathways important for meiosis, but the parts list is still poorly defined. Here we present a comprehensive catalog of genes important for meiosis in the fission yeast, Schizosaccharomyces pombe Our genome-wide functional screen surveyed all nonessential genes for roles in chromosome segregation and spore formation. Novel genes important at distinct stages of the meiotic chromosome segregation and differentiation program were identified. Preliminary characterization implicated three of these genes in centrosome/spindle pole body, centromere, and cohesion function. Our findings represent a near-complete parts list of genes important for meiosis in fission yeast, providing a valuable resource to advance our molecular understanding of meiosis.
巻・号 208(2)
ページ 589-603
公開日 2018-2-1
DOI 10.1534/genetics.117.300527
PII genetics.117.300527
PMID 29259000
PMC PMC5788524
MeSH Chromosome Segregation Genome, Fungal* Genomics* / methods Meiosis / genetics* Microbial Viability / genetics Recombination, Genetic Schizosaccharomyces / genetics* Schizosaccharomyces pombe Proteins / genetics* Sister Chromatid Exchange Spores, Fungal
IF 4.015
引用数 8
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