RRC ID |
50486
|
著者 |
Xu R, Li J, Zhao H, Kong R, Wei M, Shi L, Bai G, Li Z.
|
タイトル |
Self-restrained regulation of stem cell niche activity by niche components in the Drosophila testis.
|
ジャーナル |
Dev Biol
|
Abstract |
Most, if not all, stem cells reside in a defined microenvironment, called the niche. Short-ranged niche signal must be tightly controlled to be active only inside the niche to maintain the proper balance of stem cell self-renewal verse differentiation. However, how niche components restrict localized niche signal activation remains largely unknown. Here, we find that Thickveins (Tkv, a type I receptor of the Dpp signaling pathway) in cyst stem cells (CySCs) of the testis niche prevents Dpp signaling activation outside of the niche. We show that Tkv functions as Dpp trap/sink to spatially restrain Dpp signaling inside the niche. This self-restrained regulation of niche activity by Tkv in CySCs is independent of the canonical Dpp signaling pathway. Our data demonstrate the critical roles of niche components (CySCs) in the self-restrained regulation of niche activity, which could be shed light on niche activity regulation in general.
|
巻・号 |
439(1)
|
ページ |
42-51
|
公開日 |
2018-7-1
|
DOI |
10.1016/j.ydbio.2018.04.011
|
PII |
S0012-1606(18)30070-8
|
PMID |
29679558
|
MeSH |
Animals
Cell Differentiation / physiology
Drosophila / embryology
Drosophila / genetics
Drosophila Proteins / genetics
Drosophila Proteins / metabolism*
Drosophila Proteins / physiology
Gene Expression Regulation, Developmental / genetics
Germ Cells / cytology
Male
Protein Serine-Threonine Kinases / metabolism*
Protein Serine-Threonine Kinases / physiology
Receptors, Cell Surface / metabolism*
Receptors, Cell Surface / physiology
Signal Transduction / physiology
Stem Cell Niche / genetics*
Stem Cell Niche / physiology*
Stem Cells / cytology
Testis / metabolism
Testis / physiology
|
IF |
2.896
|
引用数 |
4
|
リソース情報 |
ショウジョウバエ |
14026R-1
7904R-2
12399R-1
12399R-2 |