RRC ID 1175
著者 Jongwutiwes S, Putaporntip C, Iwasaki T, Ferreira MU, Kanbara H, Hughes AL.
タイトル Mitochondrial genome sequences support ancient population expansion in Plasmodium vivax.
ジャーナル Mol Biol Evol
Abstract Examination of nucleotide diversity in 106 mitochondrial genomes of the most geographically widespread human malaria parasite, Plasmodium vivax, revealed a level of diversity similar to, but slightly higher than, that seen in the virulent human malaria parasite Plasmodium falciparum. The pairwise distribution of nucleotide differences among mitochondrial genome sequences supported the hypothesis that both these parasites underwent ancient population expansions. We estimated the age of the most recent common ancestor (MRCA) of the mitochondrial genomes of both P. vivax and P. falciparum at around 200,000-300,000 years ago. This is close to the previous estimates of the time of the human mitochondrial MRCA and the origin of modern Homo sapiens, consistent with the hypothesis that both these Plasmodium species were parasites of the hominid lineage before the origin of modern H. sapiens and that their population expansion coincided with the population expansion of their host.
巻・号 22(8)
ページ 1733-9
公開日 2005-8-1
DOI 10.1093/molbev/msi168
PII msi168
PMID 15901839
PMC PMC1224720
MeSH Animals DNA, Mitochondrial / genetics* Evolution, Molecular* Genes, Protozoan Genome, Protozoan* Humans Plasmodium vivax / genetics*
IF 11.062
引用数 65
WOS 分野 GENETICS & HEREDITY EVOLUTIONARY BIOLOGY BIOCHEMISTRY & MOLECULAR BIOLOGY
リソース情報
病原微生物 P. vivax?