RRC ID |
53095
|
著者 |
Hamada M, Schröder K, Bathia J, Kürn U, Fraune S, Khalturina M, Khalturin K, Shinzato C, Satoh N, Bosch TC.
|
タイトル |
Metabolic co-dependence drives the evolutionarily ancient Hydra-Chlorella symbiosis.
|
ジャーナル |
Elife
|
Abstract |
Many multicellular organisms rely on symbiotic associations for support of metabolic activity, protection, or energy. Understanding the mechanisms involved in controlling such interactions remains a major challenge. In an unbiased approach we identified key players that control the symbiosis between Hydra viridissima and its photosynthetic symbiont Chlorella sp. A99. We discovered significant up-regulation of Hydra genes encoding a phosphate transporter and glutamine synthetase suggesting regulated nutrition supply between host and symbionts. Interestingly, supplementing the medium with glutamine temporarily supports in vitro growth of the otherwise obligate symbiotic Chlorella, indicating loss of autonomy and dependence on the host. Genome sequencing of Chlorella sp. A99 revealed a large number of amino acid transporters and a degenerated nitrate assimilation pathway, presumably as consequence of the adaptation to the host environment. Our observations portray ancient symbiotic interactions as a codependent partnership in which exchange of nutrients appears to be the primary driving force.
|
巻・号 |
7
|
公開日 |
2018-5-31
|
DOI |
10.7554/eLife.35122
|
PII |
35122
|
PMID |
29848439
|
PMC |
PMC6019070
|
MeSH |
Animals
Biological Evolution*
Chlorella / drug effects
Chlorella / genetics
Chlorella / metabolism*
Conserved Sequence
Darkness
Epithelial Cells / drug effects
Epithelial Cells / metabolism
Gene Expression Regulation
Genome
Hydra / drug effects
Hydra / genetics
Hydra / growth & development
Hydra / metabolism*
Molecular Sequence Annotation
Nitrates / metabolism
Nitrogen / metabolism
Photosynthesis / genetics
RNA, Ribosomal, 18S / genetics
RNA, Ribosomal, 18S / metabolism
Species Specificity
Sugars / pharmacology
Symbiosis* / drug effects
Symbiosis* / genetics
|
IF |
7.08
|
引用数 |
6
|
リソース情報 |
藻類 |
NIES-2166
NIES-2235
NIES-2541 |