RRC ID |
36884
|
著者 |
Kawabata K, Kato Y, Sakano T, Baba N, Hagiwara K, Tamura A, Baba S, Natsume M, Ohigashi H.
|
タイトル |
Effects of phytochemicals on in vitro anti-inflammatory activity of Bifidobacterium adolescentis.
|
ジャーナル |
Biosci Biotechnol Biochem
|
Abstract |
Probiotics have been shown to improve the condition of not only the human gastrointestinal tract but also the entire body. We found that quercetin enhances the anti-inflammatory activity of Bifidobacterium adolescentis, which is abundant in human intestines. Here, we assessed whether certain phytochemicals could enhance the anti-inflammatory activity of B. adolescentis. Bifidobacteria were anaerobically cultured with phytochemicals for 3 h, and the anti-inflammatory activity of the supernatants was estimated by testing their ability to inhibit nitric oxide (NO) production by lipopolysaccharide-stimulated RAW264 macrophages. Of the 55 phytochemicals tested, phloretin, (+)-taxifolin, and (-)-epigallocatechin gallate as well as quercetin-3-O-glucoside and quercetin-4'-O-glucoside were similar to quercetin in promoting NO suppression by B. adolescentis. In addition, the phytochemicals excluding quercetin increased the concentrations of lactic and acetic acids in the co-culture supernatants. These results suggest that some phytochemicals may activate the anti-inflammatory function of B. adolescentis.
|
巻・号 |
79(5)
|
ページ |
799-807
|
公開日 |
2015-1-1
|
DOI |
10.1080/09168451.2015.1006566
|
PMID |
25721815
|
MeSH |
Acetic Acid / metabolism
Animals
Anti-Inflammatory Agents / pharmacology*
Bifidobacterium* / drug effects
Bifidobacterium* / physiology
Catechin / analogs & derivatives
Catechin / pharmacology
Cell Line / drug effects
Coculture Techniques
Dose-Response Relationship, Drug
Flavonoids
Glucosides
Lactic Acid / metabolism
Lipopolysaccharides / pharmacology
Macrophages / drug effects
Mice
Nitric Oxide / metabolism
Phytochemicals / pharmacology
Probiotics / pharmacology*
Quercetin / analogs & derivatives
Quercetin / pharmacology
|
IF |
1.516
|
引用数 |
7
|
WOS 分野
|
FOOD SCIENCE & TECHNOLOGY
BIOTECHNOLOGY & APPLIED MICROBIOLOGY
CHEMISTRY, APPLIED
BIOCHEMISTRY & MOLECULAR BIOLOGY
|
リソース情報 |
ヒト・動物細胞 |
RAW 264(RCB0535) |