RRC ID 50097
著者 Kim H, Kim H, Kwon JY, Seo JT, Shin DM, Moon SJ.
タイトル Drosophila Gr64e mediates fatty acid sensing via the phospholipase C pathway.
ジャーナル PLoS Genet
Abstract Animals use taste to sample and ingest essential nutrients for survival. Free fatty acids (FAs) are energy-rich nutrients that contribute to various cellular functions. Recent evidence suggests FAs are detected through the gustatory system to promote feeding. In Drosophila, phospholipase C (PLC) signaling in sweet-sensing cells is required for FA detection but other signaling molecules are unknown. Here, we show Gr64e is required for the behavioral and electrophysiological responses to FAs. GR64e and TRPA1 are interchangeable when they act downstream of PLC: TRPA1 can substitute for GR64e in FA but not glycerol sensing, and GR64e can substitute for TRPA1 in aristolochic acid but not N-methylmaleimide sensing. In contrast to its role in FA sensing, GR64e functions as a ligand-gated ion channel for glycerol detection. Our results identify a novel FA transduction molecule and reveal that Drosophila Grs can act via distinct molecular mechanisms depending on context.
巻・号 14(2)
ページ e1007229
公開日 2018-2-1
DOI 10.1371/journal.pgen.1007229
PII PGENETICS-D-17-02164
PMID 29420533
PMC PMC5821400
MeSH Animals Animals, Genetically Modified Aristolochic Acids / metabolism Drosophila Proteins / genetics Drosophila Proteins / physiology* Drosophila melanogaster* / genetics Drosophila melanogaster* / metabolism Fatty Acids / metabolism* Glycerol / metabolism Lipid Metabolism / genetics Maleimides / metabolism Receptors, Cell Surface / genetics Receptors, Cell Surface / physiology* Signal Transduction / genetics Taste / genetics* Type C Phospholipases / metabolism*
IF 5.175
引用数 2
リソース情報
ショウジョウバエ CAS-0001