論文 - 詳細
RRC ID | 45305 |
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著者 | Mitsuhashi S, Shindo C, Shigetomi K, Miyamoto T, Ubukata M. |
タイトル | (+)-Epogymnolactam, a novel autophagy inducer from mycelial culture of Gymnopus sp. |
ジャーナル | Phytochemistry |
Abstract |
Mushrooms, including Ganoderma lucidum, have been used as a potential source of therapeutic compounds, and an autophagy inducer would be useful for treatment of diverse diseases in human. Reported here is a full account of screening, isolation, structural determination, and biological activity of an autophagy inducer, (+)-epogymnolactam (1) from a mycelial culture of a Gymnopus sp. strain. Its structure was elucidated by HR-ESI-MS, NMR, and its plus sign by specific rotation. It exists as a tautomeric mixture of 1a and 1b in MeOH. The major tautomer of 1 is (1R,5S)-4-butyl-4-hydroxy-3-aza-6-oxa-bicyclo[3.1.0]hexan-2-one (1a), and the minor tautomeric form is (2R,3S)-3-pentanoyloxirane-2-carboxamide (1b). |
巻・号 | 114 |
ページ | 163-7 |
公開日 | 2015-6-1 |
DOI | 10.1016/j.phytochem.2014.08.012 |
PII | S0031-9422(14)00327-6 |
PMID | 25242622 |
MeSH | Agaricales / chemistry* Autophagy / drug effects* Bridged Bicyclo Compounds, Heterocyclic / chemistry Bridged Bicyclo Compounds, Heterocyclic / isolation & purification* Humans Molecular Structure Nuclear Magnetic Resonance, Biomolecular Stereoisomerism |
IF | 3.044 |
引用数 | 8 |
WOS 分野 | PLANT SCIENCES BIOCHEMISTRY & MOLECULAR BIOLOGY |
リソース情報 | |
ヒト・動物細胞 | NIH/3T3(RCB2767) |