RRC ID 30091
著者 Lloyd RG, Benson FE, Shurvinton CE.
タイトル Effect of ruv mutations on recombination and DNA repair in Escherichia coli K12.
ジャーナル Mol Gen Genet
Abstract Mutation of the ruv gene of E. coli is associated with sensitivity to radiation, and filamentous growth after transient inhibition of DNA synthesis. The filamentation of ruv strains is abolished by mutations in sfiA or sfiB that prevent SOS induced inhibition of cell division, but this does not restore resistance to UV radiation. Double mutants carrying both ruv and uvr mutations are considerably more sensitive to UV radiation than the single mutants, but there is no additive effect of ruv with recA, recF, recB, or recC mutations. ruv mutations have little effect on conjugal recombination in wild-type strains but confer recombination deficiency and extreme sensitivity to ionizing radiation in recBC sbcB strains. These results, together with the fact that ruv strains are excision proficient and mutable by UV light, are interpreted to suggest that the ruv + product is involved in recombinational repair of damaged DNA rather than in cell division as suggested by Otsuji et al. (1974).
巻・号 194(1-2)
ページ 303-9
公開日 1984-1-1
DOI 10.1007/BF00383532
PMID 6374379
MeSH Bacterial Proteins / metabolism DNA Ligases / metabolism DNA Repair* DNA, Bacterial / metabolism DNA, Bacterial / radiation effects Escherichia coli / genetics* Escherichia coli / metabolism Gene Expression Regulation* Genes, Bacterial* Recombination, Genetic*
引用数 165
WOS 分野 GENETICS & HEREDITY BIOCHEMISTRY & MOLECULAR BIOLOGY
リソース情報
原核生物(大腸菌) ME8578 ME8579 ME8580 ME8581 ME8577