RRC ID 50413
著者 Obata F, Tsuda-Sakurai K, Yamazaki T, Nishio R, Nishimura K, Kimura M, Funakoshi M, Miura M.
タイトル Nutritional Control of Stem Cell Division through S-Adenosylmethionine in Drosophila Intestine.
ジャーナル Dev Cell
Abstract The intestine has direct contact with nutritional information. The mechanisms by which particular dietary molecules affect intestinal homeostasis are not fully understood. In this study, we identified S-adenosylmethionine (SAM), a universal methyl donor synthesized from dietary methionine, as a critical molecule that regulates stem cell division in Drosophila midgut. Depletion of either dietary methionine or SAM synthesis reduces division rate of intestinal stem cells. Genetic screening for putative SAM-dependent methyltransferases has identified protein synthesis as a regulator of the stem cells, partially through a unique diphthamide modification on eukaryotic elongation factor 2. In contrast, SAM in nutrient-absorptive enterocytes controls the interleukin-6-like protein Unpaired 3, which is required for rapid division of the stem cells after refeeding. Our study sheds light upon a link between diet and intestinal homeostasis and highlights the key metabolite SAM as a mediator of cell-type-specific starvation response.
巻・号 44(6)
ページ 741-751.e3
公開日 2018-3-26
DOI 10.1016/j.devcel.2018.02.017
PII S1534-5807(18)30149-7
PMID 29587144
MeSH Animals Cell Differentiation / drug effects* Cell Self Renewal / physiology* Drosophila Proteins / genetics Drosophila Proteins / metabolism* Drosophila melanogaster / genetics Drosophila melanogaster / growth & development* Drosophila melanogaster / metabolism Enterocytes / cytology Enterocytes / drug effects Enterocytes / metabolism Female Homeostasis Interleukin-6 / metabolism Intestinal Mucosa / metabolism Intestines / cytology* Intestines / drug effects Male Methionine / deficiency Nutritional Status S-Adenosylmethionine / pharmacology* Stem Cells / cytology* Stem Cells / physiology
IF 10.092
引用数 21
リソース情報
ショウジョウバエ 9960R-2