RRC ID 31961
著者 Hu L, Huang H, Li J, Yin MX, Lu Y, Wu W, Zeng R, Jiang J, Zhao Y, Zhang L.
タイトル Drosophila casein kinase 2 (CK2) promotes warts protein to suppress Yorkie protein activity for growth control.
ジャーナル J Biol Chem
Abstract Drosophila Hippo signaling regulates Wts activity to phosphorylate and inhibit Yki in order to control tissue growth. CK2 is widely expressed and involved in a variety of signaling pathways. In this study we report that Drosophila CK2 promotes Wts activity to phosphorylate and inhibit Yki activity, which is independent of Hpo-induced Wts promotion. In vivo, CK2 overexpression suppresses hpo mutant-induced expanded (Ex) up-regulation and overgrowth phenotype, whereas it cannot affect wts mutant. Consistent with this, knockdown of CK2 up-regulates Hpo pathway target expression. We also found that Drosophila CK2 is essential for tissue growth as a cell death inhibitor as knockdown of CK2 in the developing disc induces severe growth defects as well as caspase3 signals. Taken together, our results uncover a dual role of CK2; although its major role is promoting cell survive, it may potentially be a growth inhibitor as well.
巻・号 289(48)
ページ 33598-607
公開日 2014-11-28
DOI 10.1074/jbc.M114.580456
PII S0021-9258(20)47433-2
PMID 25320084
PMC PMC4246111
MeSH Animals Casein Kinase II / genetics Casein Kinase II / metabolism* Drosophila Proteins / genetics Drosophila Proteins / metabolism* Drosophila melanogaster Intracellular Signaling Peptides and Proteins / genetics Intracellular Signaling Peptides and Proteins / metabolism Mutation Nuclear Proteins / genetics Nuclear Proteins / metabolism* Protein Kinases / genetics Protein Kinases / metabolism* Protein Serine-Threonine Kinases / genetics Protein Serine-Threonine Kinases / metabolism Signal Transduction / physiology* Trans-Activators / genetics Trans-Activators / metabolism* YAP-Signaling Proteins
IF 4.238
引用数 5
WOS 分野 BIOCHEMISTRY & MOLECULAR BIOLOGY
リソース情報
ショウジョウバエ 17520R-1 17520R-2 15224R-1 15224R-2