RRC ID 2484
著者 Liu Q, Ensign RD, Azodi E.
タイトル Cadherin-1, -2 and -4 expression in the cranial ganglia and lateral line system of developing zebrafish.
ジャーナル Gene Expr Patterns
Abstract Cadherins are cell adhesion molecules that play important roles in development of a variety of tissues and organs including the nervous system. In this study we analyzed expression patterns of three zebrafish classical (type I) cadherins (cadherin-1, -2, and -4) in the embryonic zebrafish cranial ganglia and lateral line system using in situ hybridization and immunohistochemical methods. All three cadherins exhibit distinct spatiotemporal patterns of expression during cranial ganglia and lateral line system development. cadherin-1 message was detected in the trigeminal and facial ganglia, in the lateral line ganglia, and in most of neuromasts in the lateral lines. Cadherin-2 mRNA and protein were expressed by the majority of the cranial ganglia and lateral line system. Both cadherins were found in embryos younger than 24 hours post fertilization as well as in 2-3-day old embryos and larvae. In contrast, cadherin-4 mRNA and protein expression was detected in embryos older than 30 hours post fertilization and limited to the trigeminal, statoacoustic, and vagal cranial ganglia, and the lateral line ganglia of older embryos and larvae.
巻・号 3(5)
ページ 653-8
公開日 2003-10-1
DOI 10.1016/s1567-133x(03)00109-1
PII S1567133X03001091
PMID 12972001
MeSH Animals Base Sequence Cadherins / metabolism* Cranial Nerves / metabolism* Embryo, Nonmammalian Ganglia, Sensory / metabolism* Gene Expression Regulation, Developmental Molecular Sequence Data Nervous System Physiological Phenomena Zebrafish / growth & development* Zebrafish / metabolism
IF 0.897
引用数 19
WOS 分野 GENETICS & HEREDITY DEVELOPMENTAL BIOLOGY
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