RRC ID 34869
著者 Morán T, Bernués J, Azorín F.
タイトル The Drosophila histone demethylase dKDM5/LID regulates hematopoietic development.
ジャーナル Dev Biol
Abstract dKDM5/LID regulates transcription of essential developmental genes and, thus, is required for different developmental processes. Here, we report the essential contribution of dKDM5/LID to hematopoiesis in Drosophila. Our results show that dKDM5/LID is abundant in hemocytes and that its depletion induces over-proliferation and differentiation defects of larval hemocytes and disrupts organization of the actin cytoskeleton. We also show that dKDM5/LID regulates expression of key factors of hematopoietic development. In particular, dKDM5/LID depletion up-regulates expression of several transcription factors involved in hemocytes proliferation and differentiation as well as of several small-GTPases that link signaling effectors to actin cytoskeleton formation and dynamics.
巻・号 405(2)
ページ 260-8
公開日 2015-9-15
DOI 10.1016/j.ydbio.2015.07.011
PII S0012-1606(15)30053-1
PMID 26183107
MeSH Actins / metabolism Animals Animals, Genetically Modified Cell Differentiation Cell Movement Cell Proliferation Cytoskeleton / metabolism Drosophila / embryology Drosophila / enzymology* Drosophila Proteins / physiology* Female Gene Expression Regulation, Developmental* Hematopoiesis / genetics* Hemocytes / cytology Hemocytes / metabolism Histone Demethylases / physiology* Immunohistochemistry Larva / enzymology Male Transcription Factors / metabolism Transcription, Genetic
IF 2.896
引用数 4
WOS 分野 DEVELOPMENTAL BIOLOGY
リソース情報
ショウジョウバエ 9088R-1 9088R-2 GFP-IR-1