RRC ID 47916
著者 Lai CM, Lin KY, Kao SH, Chen YN, Huang F, Hsu HJ.
タイトル Hedgehog signaling establishes precursors for germline stem cell niches by regulating cell adhesion.
ジャーナル J Cell Biol
Abstract Stem cells require different types of supporting cells, or niches, to control stem cell maintenance and differentiation. However, little is known about how those niches are formed. We report that in the development of the Drosophila melanogaster ovary, the Hedgehog (Hh) gradient sets differential cell affinity for somatic gonadal precursors to specify stromal intermingled cells, which contributes to both germline stem cell maintenance and differentiation niches in the adult. We also report that Traffic Jam (an orthologue of a large Maf transcription factor in mammals) is a novel transcriptional target of Hh signaling to control cell-cell adhesion by negative regulation of E-cadherin expression. Our results demonstrate the role of Hh signaling in niche establishment by segregating somatic cell lineages for differentiation.
巻・号 216(5)
ページ 1439-1453
公開日 2017-5-1
DOI 10.1083/jcb.201610063
PII jcb.201610063
PMID 28363970
PMC PMC5412570
MeSH Animals Cell Adhesion* Drosophila melanogaster Female Germ Cells / metabolism* Hedgehog Proteins / metabolism* Ovary / cytology Ovary / metabolism Signal Transduction* Stem Cell Niche*
IF 8.811
引用数 11
WOS 分野 CELL BIOLOGY
リソース情報
ショウジョウバエ 11561R-1 2411R-1 2125R-1