RRC ID 35665
著者 Díaz-Vásquez WA, Abarca-Lagunas MJ, Arenas FA, Pinto CA, Cornejo FA, Wansapura PT, Appuhamillage GA, Chasteen TG, Vásquez CC.
タイトル Tellurite reduction by Escherichia coli NDH-II dehydrogenase results in superoxide production in membranes of toxicant-exposed cells.
ジャーナル Biometals
Abstract Tellurite, the most soluble tellurium oxyanion, is extremely harmful for most microorganisms. Part of this toxicity is due to the generation of reactive oxygen species that in turn cause oxidative stress. However, the way in which tellurite interferes with cellular processes is not well understood to date. Looking for new cellular tellurite targets, we decided to evaluate the functioning of the electron transport chain in tellurite-exposed cells. In this communication we show that the E. coli ndh gene, encoding NDH-II dehydrogenase, is significantly induced in toxicant-exposed cells and that the enzyme displays tellurite-reducing activity that results in increased superoxide levels in vitro.
巻・号 27(2)
ページ 237-46
公開日 2014-4-1
DOI 10.1007/s10534-013-9701-8
PMID 24481550
MeSH Cell Membrane / drug effects* Cell Membrane / metabolism Escherichia coli / cytology Escherichia coli / drug effects* Escherichia coli / enzymology* Escherichia coli / metabolism Oxidation-Reduction Oxidoreductases / genetics Oxidoreductases / metabolism* Superoxides / metabolism* Tellurium / metabolism* Tellurium / pharmacology*
IF 2.479
引用数 12
WOS 分野 BIOCHEMISTRY & MOLECULAR BIOLOGY
リソース情報
原核生物(大腸菌) ME9062(BW25113) JW2279-KC JW1095-KC