RRC ID 36243
著者 Bai L, Sehgal A.
タイトル Anaplastic Lymphoma Kinase Acts in the Drosophila Mushroom Body to Negatively Regulate Sleep.
ジャーナル PLoS Genet
Abstract Though evidence is mounting that a major function of sleep is to maintain brain plasticity and consolidate memory, little is known about the molecular pathways by which learning and sleep processes intercept. Anaplastic lymphoma kinase (Alk), the gene encoding a tyrosine receptor kinase whose inadvertent activation is the cause of many cancers, is implicated in synapse formation and cognitive functions. In particular, Alk genetically interacts with Neurofibromatosis 1 (Nf1) to regulate growth and associative learning in flies. We show that Alk mutants have increased sleep. Using a targeted RNAi screen we localized the negative effects of Alk on sleep to the mushroom body, a structure important for both sleep and memory. We also report that mutations in Nf1 produce a sexually dimorphic short sleep phenotype, and suppress the long sleep phenotype of Alk. Thus Alk and Nf1 interact in both learning and sleep regulation, highlighting a common pathway in these two processes.
巻・号 11(11)
ページ e1005611
公開日 2015-11-1
DOI 10.1371/journal.pgen.1005611
PII PGENETICS-D-15-01210
PMID 26536237
PMC PMC4633181
MeSH Anaplastic Lymphoma Kinase Animals Drosophila / physiology* Mushroom Bodies / enzymology* Receptor Protein-Tyrosine Kinases / genetics Receptor Protein-Tyrosine Kinases / metabolism* Sleep / physiology*
IF 5.175
引用数 10
WOS 分野 GENETICS & HEREDITY
リソース情報
ショウジョウバエ NP1131-GAL4 (DGRC#103898) NP1004-GAL4 (DGRC#112440) and NP2024-GAL4 (DGRC#112749)