RRC ID 45540
著者 Choi S, Taylor KP, Chatzigeorgiou M, Hu Z, Schafer WR, Kaplan JM.
タイトル Sensory Neurons Arouse C. elegans Locomotion via Both Glutamate and Neuropeptide Release.
ジャーナル PLoS Genet
Abstract C. elegans undergoes periods of behavioral quiescence during larval molts (termed lethargus) and as adults. Little is known about the circuit mechanisms that establish these quiescent states. Lethargus and adult locomotion quiescence is dramatically reduced in mutants lacking the neuropeptide receptor NPR-1. Here, we show that the aroused locomotion of npr-1 mutants results from the exaggerated activity in multiple classes of sensory neurons, including nociceptive (ASH), touch sensitive (ALM and PLM), and stretch sensing (DVA) neurons. These sensory neurons accelerate locomotion via both neuropeptide and glutamate release. The relative contribution of these sensory neurons to arousal differs between larval molts and adults. Our results suggest that a broad network of sensory neurons dictates transitions between aroused and quiescent behavioral states.
巻・号 11(7)
ページ e1005359
公開日 2015-7-1
DOI 10.1371/journal.pgen.1005359
PII PGENETICS-D-15-00238
PMID 26154367
PMC PMC4495980
MeSH Animals Arousal / physiology Behavior, Animal / physiology Caenorhabditis elegans / metabolism Caenorhabditis elegans / physiology* Caenorhabditis elegans Proteins / genetics* Cell Movement / physiology* Glutamic Acid / metabolism* Neuropeptides / metabolism* Nociceptors / metabolism Receptors, Neuropeptide Y / genetics* Sensory Receptor Cells / metabolism* Sleep / physiology
IF 5.175
引用数 20
WOS 分野 GENETICS & HEREDITY
リソース情報
線虫 tm1996