RRC ID 47788
著者 Yun HM, Noh S, Hyun S.
タイトル Minocycline treatment suppresses juvenile development and growth by attenuating insulin/TOR signaling in Drosophila animal model.
ジャーナル Sci Rep
Abstract Minocycline is a broad spectrum, semi-synthetic tetracycline analog that is used to treat bacterial infection. Recently, this drug has been receiving increasing attention for its non-antibiotic properties, including anti-inflammatory, tumor suppressive, and neuroprotective effects. Drosophila is a useful model organism for studying human metabolism and disease. In this study, we investigated the effects of minocycline on juvenile development and growth in Drosophila. Feeding minocycline to Drosophila larvae suppresses larval body growth and delays the timing of pupation in a dose-dependent manner. We found that the drug treatment decreased the activated form of Akt and S6K in peripheral tissues, which suggested that the insulin/target of rapamycin (TOR) signaling had been attenuated. Specifically enhancing TOR activity in the prothoracic gland (PG), the ecdysone-generating organ, attenuated the drug-induced developmental delay, which is consistent with the critical role of PG's TOR signaling in determining pupation time. Our results reveal previously unrecognized effects of minocycline and offer a new potential therapeutic opportunity for various pathological conditions associated with insulin/TOR signaling.
巻・号 7
ページ 44724
公開日 2017-3-20
DOI 10.1038/srep44724
PII srep44724
PMID 28317899
PMC PMC5357794
MeSH Animal Structures / drug effects Animals Body Size / drug effects Drosophila Proteins / metabolism* Drosophila melanogaster / anatomy & histology Drosophila melanogaster / drug effects Drosophila melanogaster / growth & development* Drosophila melanogaster / metabolism* Ecdysone / metabolism Feeding Behavior Insulin / metabolism* Larva / drug effects Larva / growth & development Larva / metabolism Minocycline / administration & dosage Minocycline / pharmacology* Models, Animal Pupa / drug effects Pupa / growth & development Signal Transduction* / drug effects TOR Serine-Threonine Kinases / metabolism*
IF 3.998
引用数 2
WOS 分野 MULTIDISCIPLINARY SCIENCES
リソース情報
ショウジョウバエ 6975R-8