RRC ID |
45278
|
著者 |
Nishikawa H, Noshita T, Tai A, Ouchi H, Okamoto T, Saito A, Yamada T, Iomori A, Ishimata N.
|
タイトル |
Syntheses and biological activities of the proposed structure of apteniol A and its derivatives.
|
ジャーナル |
Biosci Biotechnol Biochem
|
Abstract |
We describe the syntheses of the proposed structure of diphenyl ether oxyneolignan, apteniol A and its derivatives. The diphenyl ether moiety of proposed apteniol A was formed via Ullmann ether synthesis, but the spectral data of the synthesized apteniol A did not agree with that in previous studies. The dimethyl ester derivative of the proposed apteniol A was found to enhance neurite outgrowth in PC12 cells and inhibit antigen-induced degranulation in RBL-2H3 cells.
|
巻・号 |
78(9)
|
ページ |
1485-9
|
公開日 |
2014-1-1
|
DOI |
10.1080/09168451.2014.930322
|
PMID |
25209495
|
MeSH |
Animals
Cell Degranulation / drug effects
Cell Degranulation / immunology
Ether / chemical synthesis
Ether / chemistry*
Ether / pharmacology
Lignans / chemical synthesis
Lignans / chemistry*
Lignans / pharmacology
Mast Cells / drug effects
Neurites / drug effects*
Neurogenesis / drug effects
PC12 Cells
Rats
|
IF |
1.516
|
引用数 |
3
|
WOS 分野
|
FOOD SCIENCE & TECHNOLOGY
BIOTECHNOLOGY & APPLIED MICROBIOLOGY
CHEMISTRY, APPLIED
BIOCHEMISTRY & MOLECULAR BIOLOGY
|
リソース情報 |
ヒト・動物細胞 |
PC-12(RCB0009) |