RRC ID 49675
著者 Reiten I, Uslu FE, Fore S, Pelgrims R, Ringers C, Diaz Verdugo C, Hoffman M, Lal P, Kawakami K, Pekkan K, Yaksi E, Jurisch-Yaksi N.
タイトル Motile-Cilia-Mediated Flow Improves Sensitivity and Temporal Resolution of Olfactory Computations.
ジャーナル Curr Biol
Abstract Motile cilia are actively beating hair-like structures that cover the surface of multiple epithelia. The flow that ciliary beating generates is utilized for diverse functions and depends on the spatial location and biophysical properties of cilia. Here we show that the motile cilia in the nose of aquatic vertebrates are spatially organized and stably beat with an asymmetric pattern, resulting in a robust and stereotypical flow around the nose. Our results demonstrate that these flow fields attract odors to the nose pit and facilitate detection of odors by the olfactory system in stagnant environments. Moreover, we show that ciliary beating quickly exchanges the content of the nose, thereby improving the temporal resolution of the olfactory system for detecting dynamic changes of odor plumes in turbulent environments. Altogether, our work unravels a central function of ciliary beating for generating flow fields that increase the sensitivity and the temporal resolution of olfactory computations in the vertebrate brain.
巻・号 27(2)
ページ 166-174
公開日 2017-1-23
DOI 10.1016/j.cub.2016.11.036
PII S0960-9822(16)31389-6
PMID 28041793
MeSH Animals Biophysical Phenomena Cilia / physiology* Epithelium / physiology* Nose / physiology* Odorants Olfactory Receptor Neurons / cytology Olfactory Receptor Neurons / metabolism Signal Transduction Smell* Zebrafish / physiology* Zebrafish Proteins / metabolism
IF 9.601
引用数 18
リソース情報
ゼブラフィッシュ hspGGFF19B;UAS:GFP