RRC ID 32383
著者 Nelson MD, Lee KH, Churgin MA, Hill AJ, Van Buskirk C, Fang-Yen C, Raizen DM.
タイトル FMRFamide-like FLP-13 neuropeptides promote quiescence following heat stress in Caenorhabditis elegans.
ジャーナル Curr Biol
Abstract Among the most important decisions an animal makes is whether to engage in active movement and feeding behavior or to become quiescent. The molecular signaling mechanisms underlying this decision remain largely unknown. The nematode Caenorhabditis elegans displays sleep-like quiescence following exposures that result in cellular stress. The neurosecretory ALA neuron is required for this stress-induced recovery quiescence, but the mechanisms by which ALA induces quiescence have been unknown. We report here that quiescence induced by heat stress requires ALA depolarization and release of FMRFamide-like neuropeptides encoded by the flp-13 gene. Optogenetic activation of ALA reduces feeding and locomotion in a FLP-13-dependent manner. Overexpression of flp-13 is sufficient to induce quiescent behavior during normally active periods. We have here identified a major biological role for FMRFamide-like neuropeptides in nematodes, and we suggest that they may function in a similar capacity in other organisms.
巻・号 24(20)
ページ 2406-10
公開日 2014-10-20
DOI 10.1016/j.cub.2014.08.037
PII S0960-9822(14)01050-1
PMID 25264253
PMC PMC4254296
MeSH Animals Animals, Genetically Modified Caenorhabditis elegans / metabolism* Caenorhabditis elegans / physiology Caenorhabditis elegans Proteins / metabolism* Caenorhabditis elegans Proteins / physiology Chloride Channels / genetics Chloride Channels / metabolism Drosophila Proteins / genetics Drosophila Proteins / metabolism FMRFamide / analogs & derivatives* FMRFamide / genetics FMRFamide / metabolism Feeding Behavior Gene Expression Regulation Hot Temperature / adverse effects* Locomotion / physiology Stress, Physiological / physiology*
IF 9.601
引用数 56
WOS 分野 BIOCHEMISTRY & MOLECULAR BIOLOGY CELL BIOLOGY
リソース情報
線虫 tm2427