論文 - 詳細
| RRC ID | 47243 |
|---|---|
| 著者 | Horie Y, Myosho T, Sato T, Sakaizumi M, Hamaguchi S, Kobayashi T. |
| タイトル | Androgen induces gonadal soma-derived factor, Gsdf, in XX gonads correlated to sex-reversal but not Dmrt1 directly, in the teleost fish, northern medaka (Oryzias sakaizumii). |
| ジャーナル | Mol Cell Endocrinol |
| Abstract |
In the inbred HNI-II strain of Oryzias sakaizumii, Dmy and Gsdf are expressed in XY gonads from Stages 35 and 36, respectively, similarly to the inbred Hd-rR strain of Oryzias latipes. However, Dmrt1 respectively becomes detectable at Stage 36 and 5 days post hatching (dph) in the two strains. In XX HNI-II embryos, 17α-methyltestosterone (MT) induces Gsdf mRNA from Stage 36, accompanied by complete sex-reversal in all treated individuals (MT, 10 ng/mL), while Dmrt1 mRNA was first detectable at 5 dph. In XX d-rR, MT induced Gsdf mRNA expression and sex-reversal in only some of the treated individuals. Together, these results suggest the testis differentiation cascade in XY individuals differs between the HNI-II and Hd-rR strains. In addition, it is suggested that androgen-induced XX sex-reversal proceeds via an androgen-Gsdf-Dmrt1 cascade and that Gsdf plays an important role in sex-reversal in medaka. |
| 巻・号 | 436 |
| ページ | 141-9 |
| 公開日 | 2016-11-15 |
| DOI | 10.1016/j.mce.2016.07.022 |
| PII | S0303-7207(16)30262-3 |
| PMID | 27452797 |
| MeSH | 46, XX Testicular Disorders of Sex Development / metabolism* Animals Cell Count Female Fish Proteins / genetics Fish Proteins / metabolism* Gene Expression Regulation, Developmental / drug effects Germ Cells / cytology Germ Cells / drug effects Germ Cells / metabolism Gonads / drug effects Gonads / metabolism* Male Methyltestosterone / pharmacology* Models, Biological Oryzias / genetics Oryzias / metabolism* RNA, Messenger / genetics RNA, Messenger / metabolism Sex Determination Processes / drug effects Sex Determination Processes / genetics Transcription Factors / genetics Transcription Factors / metabolism* |
| IF | 3.871 |
| 引用数 | 11 |
| WOS 分野 | ENDOCRINOLOGY & METABOLISM CELL BIOLOGY |
| リソース情報 | |
| メダカ | HdrR-II1 (IB178) d-rR/TOKYO (MT837) HNI-II (IB176) |