RRC ID 35718
著者 Ravisankar P, Lai YT, Sambrani N, Tomoyasu Y.
タイトル Comparative developmental analysis of Drosophila and Tribolium reveals conserved and diverged roles of abrupt in insect wing evolution.
ジャーナル Dev Biol
Abstract Morphological innovation is a fundamental process in evolution, yet its molecular basis is still elusive. Acquisition of elytra, highly modified beetle forewings, is an important innovation that has driven the successful radiation of beetles. Our RNAi screening for candidate genes has identified abrupt (ab) as a potential key player in elytron evolution. In this study, we performed a series of RNA interference (RNAi) experiments in both Tribolium and Drosophila to understand the contributions of ab to the evolution of beetle elytra. We found that (i) ab is essential for proper wing vein patterning both in Tribolium and Drosophila, (ii) ab has gained a novel function in determining the unique elytron shape in the beetle lineage, (iii) unlike Hippo and Insulin, other shape determining pathways, the shape determining function of ab is specific to the elytron and not required in the hindwing, (iv) ab has a previously undescribed role in the Notch signal-associated wing formation processes, which appears to be conserved between beetles and flies. These data suggest that ab has gained a new function during elytron evolution in beetles without compromising the conserved wing-related functions. Gaining a new function without losing evolutionarily conserved functions may be a key theme in the evolution of morphologically novel structures.
巻・号 409(2)
ページ 518-29
公開日 2016-1-15
DOI 10.1016/j.ydbio.2015.12.006
PII S0012-1606(15)30343-2
PMID 26687509
MeSH Animals Biological Evolution* Body Patterning Conserved Sequence* Drosophila Proteins / genetics Drosophila Proteins / metabolism* Drosophila melanogaster / anatomy & histology* Drosophila melanogaster / genetics Drosophila melanogaster / growth & development Genes, Insect Insect Proteins / genetics Insect Proteins / metabolism* Larva Nuclear Proteins / genetics Nuclear Proteins / metabolism* Phenotype RNA Interference Receptors, Notch / metabolism Tribolium / anatomy & histology* Tribolium / genetics Tribolium / growth & development Wings, Animal / anatomy & histology* Wings, Animal / growth & development*
IF 2.896
引用数 8
WOS 分野 DEVELOPMENTAL BIOLOGY
リソース情報
ショウジョウバエ 4807R-1 4807R-2