RRC ID 36787
著者 Imamura K, Asai M, Sugamoto K, Matsumoto T, Yamasaki Y, Kamei I, Hattori T, Kishimoto M, Niisaka S, Kubo M, Nishiyama K, Yamasaki M.
タイトル Suppressing effect of cordycepin on the lipopolysaccharide-induced nitric oxide production in RAW 264.7 cells.
ジャーナル Biosci Biotechnol Biochem
Abstract In this study, we focused on the anti-inflammatory effect of cordycepin, 3'-deoxyadenosine. Cordycepin potently suppressed nitric oxide production in lipopolysaccharide-stimulated RAW 264.7 cells in an adenosine receptor-independent manner. In addition, inhibitors for adenosine kinase and nucleoside transporter abrogated the action of cordycepin. Thus, we considered that intracellular metabolism cordycepin is important for the anti-inflammatory effect of cordycepin.
巻・号 79(6)
ページ 1021-5
公開日 2015-1-1
DOI 10.1080/09168451.2015.1008977
PMID 25652735
MeSH Animals Anti-Inflammatory Agents / metabolism Anti-Inflammatory Agents / pharmacology* Deoxyadenosines / metabolism Deoxyadenosines / pharmacology* Lipopolysaccharides / pharmacology* Macrophages / drug effects Macrophages / metabolism Mice Nitric Oxide / biosynthesis* RAW 264.7 Cells
IF 1.516
引用数 7
WOS 分野 FOOD SCIENCE & TECHNOLOGY BIOTECHNOLOGY & APPLIED MICROBIOLOGY BIOCHEMISTRY & MOLECULAR BIOLOGY CHEMISTRY, APPLIED
リソース情報
ヒト・動物細胞 RAW 264(RCB0535)