RRC ID 45895
著者 Ye AL, Ragle JM, Conradt B, Bhalla N.
タイトル Differential regulation of germline apoptosis in response to meiotic checkpoint activation.
ジャーナル Genetics
Abstract In Caenorhabditis elegans, germline apoptosis is promoted by egl-1 and ced-13 in response to meiotic checkpoint activation. We report that the requirement for these two factors depends on which checkpoints are active. We also identify a regulatory region of egl-1 required to inhibit germline apoptosis in response to DNA damage incurred during meiotic recombination.
巻・号 198(3)
ページ 995-1000
公開日 2014-11-1
DOI 10.1534/genetics.114.170241
PII genetics.114.170241
PMID 25217053
PMC PMC4224185
MeSH Animals Apoptosis* / genetics Caenorhabditis elegans / cytology* Caenorhabditis elegans / genetics Caenorhabditis elegans Proteins / metabolism Cell Cycle Checkpoints* / genetics Chromosome Pairing / genetics Germ Cells / cytology* Meiosis* / genetics Mutation / genetics Regulatory Sequences, Nucleic Acid / genetics Transcription, Genetic
IF 4.015
引用数 5
WOS 分野 GENETICS & HEREDITY
リソース情報
線虫 tm536 tm1458